Incendiary Lies and Uncomfortable truths about animal testing

Leishmaniasis life cycle through sand flies and humans

A recent story, complete with a picture of dogs being subjected to sand fly bites and inflammatory lies by animal rights groups, is being used to disparage Dr. Anthony Fauci as a heartless, politically motivated scientist. There are a lot of reasons to judge Dr. Fauci harshly, but this is not one of them. Let me explain.

Drug development and testing involves multiple steps to ensure safety and efficacy of a proposed drug before it is given to humans to treat disease.  In the case cited in the article from whitecoatwaste.org and echoed by PETA, lies include flies stripping flesh from bones. What is really happening is that anesthetized dogs are being infected with leishmaniasis parasites by bites from infected sand flies in order to test drugs to treat this dreadful tropical disease, which naturally infects dogs, cats, rodents, and humans by millions in tropical-subtropical regions of Africa, Middle East, southern Europe, South and Central America and even the United States.  See Leishmaniasis Facts:  below for more details about this disease. 

The flies are not “stripping the flesh from the bones” as described in the article.  Sand fly bites are like mosquito bites, not like being eaten by carrion or blow fly maggots, which this lie implies.  After being infected with the parasite through several sand fly bites, the dogs will be treated for the disease by an experimental drug to see how effectively it cures them, and to determine any unpleasant or dangerous side effects of the drug. 

Animal testing is a necessary, though disgusting, step in drug development. To ethically carry out this type of procedure, suffering of the animals must be minimized.[1.] That is why the dogs are anesthetized and only their heads are exposed to the sand fly bites. Dogs are the best model for this disease since it naturally infects dogs with a visceral form that can be fatal if untreated. This may be a part of development of veterinary treatment drugs, but it may be used for human drugs as well.

All drugs and cosmetics, as well as many other consumer products, are tested first on cell cultures and then on animals for both safety and effectiveness before graduating to human trials.  Covid vaccines and treatment drugs were tested on animals such as genetically modified mice before human trials, but without outrage because there was no cute pet sentimental propaganda.

Animal testing is a necessary step that, though sensibly abhorrent, must be done.  Eliminating testing of animal models would mean that drugs, cosmetics or other products would be given to humans without knowing if they might be harmful or be effective for the proposed purpose.  Typical animal models used for product development include a variety of vertebrates including dogs, cats, monkeys, Guinea pigs, hamsters, rats and mice. Animal models used to gauge a product’s potential for environmental pollution also include fish, crustaceans like crabs, mollusks like snails, as well as single cell, colony and other microscopic animals.

If a cosmetic or household product advertises that it is not tested on animals, it only means that the ingredients underwent animal tested by others in the past. Re-blending of well-known ingredients may not need more animal testing for each new mixture within reasonable variability.

It is true that animal models are not perfect matches for reactions in humans. Each animal has unique metabolic systems that vary from species to species.  What developers try to do is to match human systems as well as possible for the disease and the mechanism of the drug being developed.  For instance, some products are affected by whether or not an animal can make its own vitamin C. Humans cannot and have that in common with hamsters, which are sometimes used for toxicology and other testing.

Both White Coat Waste and PETA (People for the Ethical Treatment of Animals) are advocacy groups that are dedicated to ending animal testing of all types.  Ending animal testing would end drug, cosmetic and consumer product development.  As much as I wish we could end animal testing, this is not possible unless we stop all progress, development or improvement of treatments for still orphaned diseases and conditions.

For example, the progress made by St. Jude in childhood leukemia and cancer treatment is remarkable. At one time, fatality was 80 to 90% for most types. Now, for most of these diseases, fatality is only 20%.  This is still too high, but could not have been accomplished without new drug and treatment development.  My daughter died over 40 years ago of a type of leukemia that is among those types that still have high fatality. Much research and development is still needed.

Leishmaniasis Facts:  Leishmania is caused by a protozoan parasite carried and spread by infected sand flies. Sand flies are tiny, about half the size of mosquitos, and are silent.  They are most active dusk to dawn.  Only females need blood for egg and parasite development.  Sand flies become infected by biting and taking a blood meal from infected dogs, cats, rodents or humans, so a few cases have now been acquired in Texas, probably by sand flies that had bitten immigrants from tropical countries.

Symptoms of visceral leishmania in humans, which may not be evident for months or even years, include fever, weight loss, enlarged spleen and liver, abnormal blood tests with low red and white cells and platelets and may cause kidney failure. The cutaneous form affects skin with nodules and ulcers that develop in a few weeks, but may progress to the visceral form even after the sores heal.

Symptoms in dogs include skin nodules, thickening of foot pads, dull and brittle hair and hair loss patches. Visceral symptoms include fever, loss of appetite, weakness, exercise intolerance, severe weight loss, diarrhea, vomiting, bleeding nose, tarry stools, swollen lymph nodes, enlarged spleen, kidney failure.

Treatment:  No one treatment is effective for all cases. It varies with the form and the species/strain of the parasite, and even the geographical location.  CDC offers advice for several possible treatments, but does not ensure success for any one of them.  Some are not available in developing countries, and some are not available in the United States because the FDA had not approved them.  There is a need for development of vaccines and better treatments with a more assured outcome for all strains in all areas.

Full disclosure: Most of my knowledge about drug development protocols was gained while I worked for a pharmaceutical company for five years in the 1990s. I was a supervisor in a chemical control lab that tested FDA approved prescription drugs.  I was not directly involved in research and development or with testing experimental drugs on animals, but both were located at the same company site.  Animal rights protests and violence prompted the company to build a high security fence that included parking lots in order to protect employees.  

[1.] “In an emailed statement to MedPage Today, NIAID said the contract for “preclinical pharmacology and toxicology services” was conducted “as required in animal models by the FDA, in compliance with Good Laboratory Practice (GLP) guidelines and in a facility accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) or its equivalent.” from https://www.medpagetoday.com/special-reports/exclusives/95275 Oct. 26, 2021

Why the Leftist Backlash Against Ivermectin

Ron Clutz's avatarScience Matters

Connor Harris explains in his City Journal article Try a Dose of Skepticism.  Excerpts in italics with my bolds.

Ivermectin may or may not work against Covid-19, but media coverage of the drug has been sneering, inaccurate—and revealing.

“You are not a horse. You are not a cow. Seriously, y’all. Stop it,” read a recent viral tweet warning readers away from using a certain medication to treat Covid-19. The tone of affectedly folksy condescension would be expected from any of thousands of Twitter-addicted progressive journalists, but less so from the official account of the United States Food and Drug Administration. Perhaps even more surprising, the tweet linked to a warning advising readers not to take a drug, ivermectin, that has been used in humans for decades and is a standard Covid-19 treatment in much of the world.

The media’s recent reporting on ivermectin is a fitting sequel to their…

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Nebraska AG Frees Doctors and Patients to Use HCQ and IVM

Ron Clutz's avatarScience Matters


Jim Hoft reports at Gateway Pundit Nebraska AG Issues Opinion on Doctors Prescribing HCQ and Ivermectin for COVID Treatment Will Not Face Punishment. Excerpts in italics with my bolds.

The Office of the Attorney General in Nebraska issued an opinion Friday in response to the request of the Nebraska Department of Health and Human Services that states there’s no “clear and convincingevidence that a physician who first obtains informed consent and then utilizes Ivermectin or hydroxychloroquine for COVID-19 violates the UCA (Nebraska’s Uniform Credential Act).”

Nebraska Attorney General Doug Peterson together with his Solicitor General and Assistant Attorney General issued their opinion in response to a request by Nebraska Department of Health and Human Services CEO, Dannette Smith. She wanted the AG’s office to examine carefully whether doctors could face legal action or be subject to discipline if they prescribed the meds for COVID treatment.

“Allowing physicians to consider…

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Stop Big Pharma Using Little Pharma Against Ivermectin

Ron Clutz's avatarScience Matters

For decades Big Pharma co-opted physicians to prescribe their products over those from competitors. The biggest winnings came when a new patent drug had no competition. And of course, when the patents run out, the generics take over the supply. With the Covid pandemonia, a new dynamic arose to protect vaccine profits against anti-viral generic drugs, especially HCQ and Ivermectin. Daniel Horowitz explains at Blaze Media Louisiana AG Jeff Landry warns pharmacies against blocking COVID treatment. Excerpts in italics with my bolds.

“Never have pharmacists been allowed to practice medicine and get between a doctor and his patient,”stated Louisiana Attorney General Jeff Landry in an interview with TheBlaze. “Most certainly not in middle of a pandemic.”

State attorney general might not be the elected position that comes to mind when assessing the pandemic response, but Landry believes that his counterparts in other states have a vital role to play…

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“Climate Emergency” – Nothing But Politics And Propaganda Unsupported By Scientific Data — Watts Up With That?

The “climate emergency” claim hyped by Scientific American and other political climate alarmist entities is based on the completely fallacious statement that “the planet is heating up way to fast” with that flawed claim representing nothing but politics and propaganda that is disproved by actually measured global temperature anomaly temperature measurements between 1988 and 2021 as well as being directly contradicted by the…

“Climate Emergency” – Nothing But Politics And Propaganda Unsupported By Scientific Data — Watts Up With That?

Doctors Told To Cut Treatment To Tackle Climate Change — NOT A LOT OF PEOPLE KNOW THAT

By Paul Homewood h/t Ian Magness This is utterly criminal. And why is the Telegraph’s Health Reporter crticising this nonsense?

Doctors Told To Cut Treatment To Tackle Climate Change — NOT A LOT OF PEOPLE KNOW THAT

Afghanistan rescue ops in progress – Western Journal

US Special Ops Veterans Form Their Own Squad, Travel to Kabul for Extremely Dangerous Rescue Mission

 By Dillon Burroughs  August 27, 2021 at 9:35am

A volunteer group of American veterans launched a final mission on Wednesday night, dubbed “Pineapple Express,” to reportedly help hundreds of members of Afghan elite forces and their families reach safety.

The group, dubbed Task Force Pinapple, operated in darkness to help those at risk.

“As of Thursday morning, the group said it had brought as many as 500 Afghan special operators, assets and enablers and their families into the airport in Kabul overnight, handing them each over to the protective custody of the U.S. military,” ABC News reported.

“That number added to more than 130 others over the past 10 days who had been smuggled into the airport encircled by Taliban fighters since the capital fell to the extremists on Aug. 16 by Task Force Pineapple, an ad hoc groups of current and former U.S. special operators, aid workers, intelligence officers and others with experience in Afghanistan who banded together to save as many Afghan allies as they could.”

The group was led by Army Lt. Col. Scott Mann, who leads an organization called Rooftop Leadership. Mann is a retired Green Beret commander.


“We made a commitment to get them out and this is our chance to do the right thing. And I’m telling you if we don’t, Brianna, it’s going to haunt us for a very, very long time,” Mann said during a CNN interview on Monday.

Trending:US Special Forces Vets Go Rogue in Middle of Night, Rescue Afghan Allies That Biden Won’t

GoFundMe page offered supporters an opportunity to donate to the group’s expenses.

The Left’s Propaganda Methods Revealed

from The American Mind, Claremont Institute https://americanmind.org/salvo/thats-not-happening-and-its-good-that-it-is/#null

07.26.2021

“That’s Not Happening and It’s Good That It Is”

Michael Anton

Single Yellow Electric Megaphone Chat Bubble On Modern Background

A quick and dirty guide to regime propaganda

Gaslighting getting you down? Feel like the regime has dialed the Megaphone up to, and past, eleven? You’re not crazy. It’s definitely happening and likely to get worse as our masters’ ability to cope with reality further worsens—or worse, they gain the complete and absolute control they seek. They’re both scornful and terrified of dissent, which explains why they incessantly shriek at us and lie to our faces.

So, to help you navigate the twitstorm, I present a guide to seven of the regime’s most common, oft-deployed lies. This is not meant to be comprehensive. I’m sure there are tactics they use that either I haven’t crystalized or that aren’t front-of-mind at the moment. I encourage others to expand the catalogue with their own observations. The better we can understand how they try to manipulate us, the better we can resist and counter it all.

Let’s start with the Unholy Trinity of ruling class horse manure. These first three are similar, but subtle differences determine the ways they’re used in differing circumstances.

The Law of Merited Impossibility

The coinage is Rod Dreher’s and goes back to the early debates on homosexual marriage. As Dreher formulates it, the Law of Merited Impossibility holds: “That will never happen, and when it does, boy will you [homophobes, transphobes, racists, sexists, whatever] deserve it.”

This Law is used, first, to disarm resistance to the latest leftist enthusiasm. Whatever the innovation is, it will have no adverse consequences. None! Puberty blockers and disfiguring surgeries have no downsides whatsoever. How dare you suggest they might!

Its second purpose is to dismiss out of hand “slippery slope” arguments—despite, or because of, the fact that every single such argument over the last twenty years at least has proved true. Worried that allowing people to “self-identify” as whatever sex they want will lead to pervy 50-year-old men exposing themselves to’ tween girls? Insist, loudly and indignantly, that that will NEVER happen and anyone who suggests it might is an alarmist bigot with a heart full of hate.

The third purpose is to enforce the new caste system. Those who get to impose fresh irrational indignities on the rest of us are the upper caste. Those who object, or even have reservations, are lower. The latter are not allowed to harbor, much less express, any doubts. Whatever humiliation the upper caste has planned for us, we deserve and must meekly accept. Hence when said pervy 50-year-old actually does start waving around “her” equipment in the girls’ locker room, if any parent dares object, let ’em have it with both barrels. That thing that ten seconds ago you said would “never” happen? Now it’s righteous punishment for the retrograde.

The Law of Merited Impossibility has done wonders for the Left in helping to ram through a wide variety of radical societal changes and cow into silence all opposition. It’s currently busy destroying girls’ and women’s sports, an outcome that we were assured would “never” happen. Though one wonders what the ladies did do to deserve it.

The Law is a bit passé, though, because our rulers rarely any longer feel the need to reassure normie Americans that everything will turn out OK, that the things we most fear won’t happen. Mostly, the holders of the Megaphone just skip to the second half, the angry insistence that we deserve it

The Celebration Parallax

A parallax is the apparent difference in position of the same object seen from different vantage points. For instance, an analogue speedometer that reads sixty miles per hour to the driver, but fifty to the passenger—even though the needle itself is only in one place.

The Celebration Parallax may be stated as: “the same fact pattern is either true and glorious or false and scurrilous depending on who states it.” In contemporary speech, on any “controversial” topic—or, to say better, regime priority—the decisive factor is the intent of the speaker. If she can be presumed to be celebrating the phenomenon under discussion, she may shout her approval from the rooftops. If not, he better shut up before someone comes along to shut him up.

Note also that the key distinction here is celebration versus non-celebration, not support versus opposition. One need not actually, clearly oppose the subject under discussion in order to be blameworthy. Declining or neglecting to celebrate it forcefully enough is enough. As in Stalin’s Russia, lack of enthusiastic clapping is regarded as opposition. The legitimacy of one’s right to state the same identical fact, in the same identical language, depends on who one is and what one thinks of it. Since the left presumes that all persons of color approve of the phenomena covered by the Celebration Parallax, the Parallax is really a test to distinguish allies from Deplorables.

To the best of my recollection, the origin of the Celebration Parallax arose from the need to defend “affirmative action,” a very unpopular policy since its inception. The party line therefore goes like this: People of color must be granted explicit preferences to overcome America’s “legacy of racism” so that we may “diversify” America’s power centers and end white male dominance, a move that—in addition to being necessary to address the country’s inherent racism—improves those institutions by infusing them with different and hitherto neglected points of view. Also, kids of color need “role models” who “look like themselves.”

But there is no such thing as “reverse discrimination,” which is itself a racist term, and there are no “quotas” (another racist term) whatsoever, but only “timetables,” “goals,” and measures to evaluate applicants and candidates “holistically.”

On no subject is the Parallax more prevalent than immigration. Depending on who’s doing the talking, the demographic transformation of the United States is either a glorious trend that portends a permanent Democratic majority and a more “vibrant” future, or else a “conspiracy theory” that is not happening in any way at all, no-how.

The Left insists that concerns from certain quarters that immigration policy in America (and Europe) amounts to a “great replacement” is a “dangerous,” “evil,” “racist,” “false” “conspiracy theory.” But a leftist New York Times columnist can write an article entitled “We Can Replace Them” and … nothing. Same fundamental point, except she’s all for it and her targets aren’t. A U.S. Senator can exult that demographic change will doom Republicans. Joe Biden himself can refer to an “unrelenting stream of immigration.” Except they’re celebrating it and calling for it. Anyone on the Right who uses the exact same words will not merely be denounced; the very fact pattern that is affirmed when Biden says it will be denied when the Rightist repeats it.

The Law of Salutary Contradiction

Which brings us to the Law of Salutary Contradiction, whose formulation is: “That’s not happening and it’s good that it is.” While the Law of Merited Impossibility applies to the future, this one is about the present. It’s what the ruling class immediately switches to after what they insisted would “never” happen is happening before everyone’s eyes.

Is the NSA spying on Tucker Carlson? That’s an insane conspiracy theory … which is also warranted by Tucker’s treasonous contacts with Russian officials as he seeks an interview with Putin.

Is the Biden Administration inviting in illegal immigrants, then putting them on military planes and shipping them to the heartland? Absolutely not … and these future Nobel Prize winners deserve their shot at the American Dream.

Once you learn to recognize this pattern, you see it everywhere. It is the cornerstone of ruling class rhetoric in the current year.

The Smails Exhortation

Turning from the Unholy Trinity, we see that the ruling class condemns all of us as entitled boors. In their eyes, we deserve nothing. We have no reasonable wants nor any just complaints. Our only role is to accept getting nothing and learning to like it.

Our masters bleat about “democracy” but have redefined the word to mean “getting exactly what we”—i.e., they—“want.” Any ostensibly “democratic” outcome that might result in us getting what we want is ipso facto illegitimate. Border wall? Fascist! Immigration enforcement? Racist and fascist! Law and order? Double racist and fascist! Better trade deals? Economically illiterate! An end to endless wars? Catastrophic! And also, somehow, “anti-Semitic.” Penis-free girls’ bathrooms? Transphobic!

No matter is too small, too local, too private, or too inconsequential to escape their gaze and slip their punishment. Bake the cake, bigot.

Mostly what they bleat, though, is anti-American, anti-white, anti-conservative, anti-Christian, anti-rural, anti-Southern, anti-Red-state, anti-redneck, anti-working-class hate. Every media organ and cultural citadel blares this message loudly and incessantly.

The purpose is hard to figure. On one hand, it’s demoralizing, which certainly serves ruling class ends, and it fires up their coalition. On the other hand, if you’re trying to boil a frog, it’s best not to tell him the plan, as he might try to jump out of the pot.

Which brings us to:

The Lie-Back Imperative

This tactic, and the next one, are related to what Steve Sailer has called “The War on Noticing.”

The regime knows it’s in a difficult rhetorical position. The heart of its argument is that some people are inherently innocent and good while others are inherently guilty and bad and must be treated accordingly. To ears insufficiently attuned to this new understanding of justice, this can sound unjust. Tying moral worth to circumstances of birth? Not treating people equally? Punishing the living for the sins of the dead?

Why all this is—contrary to appearances, logic, and common sense—“just” requires considerable explanation. To the extent that people “get it,” they will sharply divide between those who say that the “advantaged” have it coming and those who object “No, I don’t.”

The problem for the regime, therefore, is that while its message is very effective at egging on its own side, it can be equally effective at alarming and rousing its targets. The ideal solution would be to come up with a public message that rallies the regime’s base while lulling its targets, but this turns out to be very difficult, if not impossible.

Another option is to forbid the targets from speaking up—hence the Celebration Parallax.

But the regime’s preferred mode is not merely to allow its targets to speak, but to require it—so long as the targets deny the regime apparatchik said what she said. Hence the response to “You are evil and deserve what’s coming to you” must be “You don’t think ill of me and wish me no harm.” Every punch in the face must be publicly rationalized, by the victim, as a massage. The purpose is partly to bully the frog into staying in the pot and partly a matter of humiliation. In the oft-quoted words of Anthony Daniels, “a society of emasculated liars is easy to control.”

A great many “conservatives” are not merely willing but eager to play along. Indeed, whole institutions of the establishment “Right” do little else but reassure their ostensible constituency that the Left not only doesn’t mean its proto-genocidal rhetoric but isn’t even saying it.

It is an odd feature of the current year that calling an avowed enemy a liar—publicly insisting that her plain words could not possibly mean what they plainly say—not only fails to provoke an angry denial but is welcomed by the liar herself. Anything to keep the regime’s targets somnambulant for as long as possible. The more Americans who wake up and realize that contemporary leftism is a revenge plot with themselves as its targets, the more will object and try to stop it. This is what the regime, at present, most fears and is trying to prevent.

The Enmity Counteraccusation

This one is perhaps the most brazen. As I put it elsewhere, “the enemy calls you its enemy for recognizing its enmity.”

As regime hacks spew vile, borderline—and sometimes explicitly—violent rhetoric at you, they will immediately wheel and counterattack if you dare object. Don’t appreciate being called evil because of your race? Then you are “divisive”! Dare put up your hands to block an incoming punch? That’s violence! You’re just supposed to take it.

They’re enemies who treat you like enemies while they insist that you treat them as friends. At least, though, unlike the housebroken “Right,” they stab you in the front.

A related point is that if you so much as speculate as to where their insane vitriol might lead the country, you will be accused of wishing for that outcome. It’s entirely possible that decades of anti-American, anti-white, anti-Christian animosity, coupled with nation-destroying trade, immigration and foreign policies, will not lead to civil war. Then again, it’s entirely possible that they might. If they do, the ruling class and the Left will bear the blame. Naturally, though, they will blame us.

Indeed, they already are. Attempts to head off such a conflict by warning about it are treated as provocations intended to produce said conflict. One can be forgiven for wondering if their plan is to start it and then say we started it, sort of like insisting Poland triggered the Second World War by shooting back.

“You’re worthless, baby; and if you even think of trying to leave me, I’ll kill you”

Which brings us to the last. Deplorable Americans are loudly and incessantly said to be the worst people in the history of the planet, pure unadulterated evil, with no legitimate concerns, interests or grievances.

Well, OK. Then why live with us? Why treat as anathema even the most moderate, banal, attempt to allow some measure of federalism and local control?

There can only be two answers: either our masters know (or intuit) deep down that we can live without them but they can’t live without us, or else they want to keep us around to administer what they view as deserved punishment.

Being neither a psychiatrist nor a theologian, I could not say whether the roots of this behavior are psychotic or demonic, but in this layman’s judgement, it exhibits key characteristics of both.

But understand this: they hate you and want you cancelled and ostracized, or at least utterly subservient and obedient. You owe them no consideration. Their every argument, every sentence, every word are proffered in bad faith. As Mary McCarthy said of Lilian Hellman, “Every word she writes is a lie—including ‘and’ and ‘the.’”

The regime is powerful, which means we must calibrate our resistance carefully. But to think clearly, our minds must be free. Which requires understanding its rhetoric and seeing through it. I hope this short guide is useful in that effort.

Michael Anton is a lecturer and research fellow at Hillsdale College and a senior fellow at the Claremont Institute.

Unmasking Biden’s Climate Shakedown

Ron Clutz's avatarScience Matters

kn121419dapc20191213114523

At Spectator, Real Jean Isaac explains How to End Biden’s Fake Climate Apocalypse.  Excerpts in italics with my bolds and images.

If there’s no pushback against the Left, we’ll see a dramatic drop in our standard of living.

With the wave of executive orders and legislation coming from the Biden administration, and the cultural antics of his woke supporters, Biden’s war on fossil fuels has received insufficient attention. Yet energy is the lifeblood of our economy, and making traditional energy sources vastly more expensive is the single most destructive aspect of Biden’s policies. If this country does not successfully mobilize against these policies, the vast majority will experience a dramatic drop in their standard of living.

mrz012921dbp20210129124515Supposedly the assault on fossil fuels — via regulation; cancellation of pipelines; concocting a huge, wholly imaginary “social cost of carbon”; taxes; and solar and wind mandates — is necessary to save…

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Keystone XL Pipeline Canceled — IER

The sponsor of the Keystone XL crude oil pipeline has canceled the project after Canadian officials failed to persuade President Joe Biden to reverse his cancellation of the presidential border crossing permit by executive order. Calgary-based TC Energy will work with government agencies “to ensure a safe termination of and exit from” the partially built…

Keystone XL Pipeline Canceled — IER